In contrast, in the absence of the cognate epitope [54] after infection with virus mCMV-NLVAla, CD8 T cells do not infiltrate infected tissue at all, can thus not form NIF, and, accordingly, allow more widespread infection visible as many foci of infection (IF), with the consequence of virally-caused tissue pathology (Fig 4A). The gene discussed is CD8A; the disease is infection.