After infection of HLA-A2.1 transgenic, constitutively combined-immunodeficient NOD/SCID/IL-2rg-/- (NSG/HHD) mice, which lack cells of adaptive immunity and are additionally deficient in natural killer (NK) cells [27], mCMV-NLV resulted in a rapid systemic infection that could be effectively combated by adoptively transferred human NLV-specific CD8 T cells as well as by human T cells transduced with an NLV-specific TCR. Here, CD8A is linked to infection.