As shown in Fig 6C, spleen cells from the lymphoma bearing mice with intra-tumorally injected DCs demonstrated a fourfold increase in producing IFNγ, when compared with the spleen cells from the normal saline or gemcitabine treated mice; the spleen cells from the lymphoma bearing mice that were sequentially treated with gemcitabine and DCs showed a tenfold increase in the stimulation of IFNγ production; co-injection of MDSCs and DCs after gemcitabine treatment reversed the increased the production of IFNγ at a level less than the lymphoma bearing mice treated with DCs alone. The gene discussed is IFNG; the disease is lymphoma.