ASPG and acute lymphoblastic leukemia: L-asparaginase (L-asparagine aminohydrolase, EC 3.5.1.1) is an important enzyme as therapeutic agents used in combination therapy with other drugs in the treatment of acute lymphoblastic leukemia in children, Hodgkin disease, acute myelocytic leukemia, acute myelomonocytic leukemia, chronic lymphocytic leukemia, lymphosarcoma treatment, reticulosarcoma, and melanosarcoma [1, 2].