TP53 and neoplasm: Although literature refers to the fact that miR-125b is a negative regulator of p53 and its expression would allow a more effective suppression of p53 pathways leading to tumor development [3, 20, 26, 27], it has been shown that overexpression of miR-125b leads to decreased cell proliferation, apoptosis, and suppression of tumor growth by targeting the PI3K/Akt/mTOR signaling pathway [28].