Other effects of LDMC relevant to beneficial immune responses in cancer include a shift in the cytokine profile from Type 2 to Type 1 [35, 37-38], proliferation and prolonged survival of lymphocytes [39], particularly effector Th1 T cells [15, 35], DC mobilization [40], activation of CD11b myeloid cells, and sensitization of tumor cells to TRAIL-dependent lysis by CD8+ cytotoxic T cells [41]. The gene discussed is CD8A; the disease is cancer.