In light of the specific forms of hormesis discussed in this paper, a repositioning of anti-cancer agents, radiation therapy, and the use of combinations of carefully determined metronomic low doses of chemotherapeutic drugs, focused radiation therapy, mTOR inhibitors, and immunotherapeutic agents that modulate the immune system to achieve optimum anti-tumor activity may well prove to be the way forward in the successful therapy of a wide range of cancers. The gene discussed is MTOR; the disease is neoplasm.