Oral administration of pomegranate fruit extract (0.1% and 0.2%, w/v) in drinking fluid to athymic nude mice implanted with androgen-dependent prostate cancer cells (CWR22Rv1) resulted in a significant inhibition in tumor growth concomitant with a significant reduction in secretion of PSA in the serum. The gene discussed is KLK3; the disease is Familial prostate cancer.