MIF and breast cancer: Toi and colleagues demonstrated that pomegranate fermented juice polyphenols possess antiangiogenic properties mediated by VEGF downregulation in ER+ breast cancer cells (MCF-7) and immortalized normal human breast epithelial cells (MCF-10A) and upregulation of the angiogenic suppressor migration inhibitory factor (MIF) in ER− breast cancer cells (MDA-MB-231).