Furthermore, the inhibition of CXCL12/CXCR4 axis was confirmed by the evaluation of the effect of luteolin, punicic acid, and ellagic acid combination (i.p., 64 μg/component/day) on the formation of metastasis and the expression of CXCR4 on luciferase expressing human prostate cancer cells (PC-3M-luc) implanted in SCID mice. Here, CXCL12 is linked to prostate cancer.