On the other hand, pomegranate juice and the combination upregulated genes involved in cell adhesion, in particular E-cadherin in PC3 cells, claudin 1 (CLDN1) in MCF7 cells, and intercellular adhesion molecule 1 (ICAM1) and myristoylated alanine-rich protein kinase C (MARCKS) in both tumor models [82, 109]. Here, CLDN1 is linked to neoplasm.