Resveratrol mediated chemopreventive effects against prostate cancer by reducing cell proliferation, insulin-like growth factor-1, and simultaneously downregulating the phosphorylated and activated MAP kinases called extracellular regulating kinase, ERK-1 and ERK-2 [45], which are involved in pathogenesis of prostate cancer [45]. This evidence concerns the gene MAPK1 and Familial prostate cancer.