PPARGC1A and Werner syndrome: RV positively influences telomeres length promoting the expression of Werner syndrome ATP-dependent-helicase, a telomere maintenance factor [61, 62]; this protection is important for mitochondrial efficiency and oxidative stress defenses because telomere shortening, activating p53 represses the transcription of the peroxisome proliferator-activated receptor gamma coactivator-1 alpha (PGC-1α) and impairs mitochondrial function [63].