RV increased cAMP and modulated Akt pathway in cell model studies [66]; besides, RV activates AMP protein kinase-SIRT1 autophagy pathway in PD cell model studies [67], upregulates antiapoptotic Bcl-2 protein, and downregulates Bax protein expression [68] and also acts as mitochondrial antioxidant by elevating the levels of antioxidants thioredoxin-2 (TRX2) and X-chromosome-linked inhibitor of apoptosis protein [69]. The gene discussed is TXN2; the disease is Parkinson disease.