MAPK8 and Insulin resistance: By using methylglyoxal (MG) as a tool to induce insulin resistance in HepG2 cells, Cheng et al. [80] demonstrated that resveratrol activated ERK pathway but not the p38 or JNK pathways, and this eventually led to Nrf2 nuclear translocation and elevation of HO-1 and glyoxalase expression levels.