Stilbenes and GSEs appear to mediate the attenuation of inflammation and insulin resistance apparently by suppressing the activation of extracellular signal-regulated kinase (ERK), c-Jun N-terminal kinase (JNK), and NF-κB (nuclear factor kappa-light-chain-enhancer of activated B cells) [164, 165], but the anti-inflammatory property may also involve the SIRT1 pathway [166]. The gene discussed is MAPK8; the disease is Insulin resistance.