LEP and obesity due to melanocortin 4 receptor deficiency: Furthermore, to detect the effect of overweight/obesity in PCOS subjects, OW/OB PCOS subjects had significantly higher leptin concentrations and FLI than lean PCOS subjects (p = 0.013; p = 0.000), respectively, and a significant reduction for sOB-R was detected between the two groups (p = 0.042), respectively.