SIRT1 is ubiquitously expressed within different structures [31, 32], and it is not new that it is involved in several ocular pathologies including uveitis [4–8, 33–35] where SIRT1 exerts eye protection through reduction of cellular and molecular inflammatory responses, LPS-induced oxidative damage, and redox-sensitive NF-κB deactivation [6]. This evidence concerns the gene NFKB1 and uveitis.