SDC4 and neoplasm: Of the 63 hubs, seven are annotated as well-known tumor suppressor genes, including MET, DUSP6, DKK1, TES, ITGB1, PTPRK, and TNFRSF10B. It is worth noting that somatic mutations in seven hub genes—EGFR, MET, MYO5A, PLAG1, PTPRK, SDC4, and HMGA2—have been implicated in cancer.