Additionally, the identification of the RIDD mechan ism, through which IRE-1α can splice mRNAs containing a specific consensus sequence which is recognized by the RNase domain [120], suggests that genetic and pharmacological results may vary, depending for instance on the type of cancer, or lead to activation of other secondary pathways.For instance, pharmacological inhibition of the RNase domain of IRE-1α predominantly blocked splicing of XBP1, while RIDD remained intact [121]. This evidence concerns the gene ERN1 and cancer.