S100B and coronary artery disorder: Also, our results demonstrated that the serum S-100β of CHD patients in the on-pump group were significantly higher than those of patients in the off-pump group (SMD = 1.08, 95 % CI = 0.67 ~ 1.48, P < 0.001), especially within 24 h after surgery (0 h: SMD = 2.91, 95 % CI = 1.64 ~ 4.19, P < 0.001; 6 h: SMD = 1.19, 95 % CI = 0.56 ~ 1.83, P = 0.017; 24 h: SMD = 0.51, 95 % CI = 0.09 ~ 0.92, P = 0.001); after 24 h, the results revealed no such statistical significance (48 h: SMD = 0.29, 95 % CI = −1.03 ~ 1.61, P = 0.670; 72 h: SMD = 0.02, 95 % CI = −0.55 ~ 0.59, P = 0.952) (Fig. 4a).