However, the suppression of proinflammatory cytokine responses by monocytes of patients with axSpA is rather minor and accompanied by a strong suppression of anti-inflammatory IL-10 production, whereas the state of endotoxin tolerance and monocyte paralysis, as for instance observed in patients with sepsis, is characterized by a strongly suppressed proinflammatory response and partly preserved IL-10 production [23]. The gene discussed is IL10; the disease is Sepsis.