SHANK2 and autism spectrum disorder: Indirect support for a link between elongation rate and altered mental status (cf. KIF3C4N-hCR) (243,244) comes from computational studies noting that SHANK-2 and SHANK-3, but not SHANK-1, demonstrate traditional 'codon-use-bias', suggesting that a translational regulatory mechanism may underly SHANK mediated autism spectrum disorders (245).