Allelic variation in loci encoding-N-hCR-bearing-genes, such as KCNA3, CFTR, SLC26A9, SCARB1, IRS2, F5, FGB and SHANK1, have been associated with diabetes, pancreatitis, lipidystrophy, vascular disorders and neurological changes (140–144). The gene discussed is CFTR; the disease is diabetes mellitus.