Allelic variation in loci encoding-N-hCR-bearing-genes, such as KCNA3, CFTR, SLC26A9, SCARB1, IRS2, F5, FGB and SHANK1, have been associated with diabetes, pancreatitis, lipidystrophy, vascular disorders and neurological changes (140–144). This evidence concerns the gene IRS2 and diabetes mellitus.