ARID5B encodes part of a histone lysine demethylase complex (363) and is not only genetically associated with ALL (266,364–369) but is also associated with corneal changes (370), low birth weight (371), diastolic blood pressure (372) rheumatoid arthritis (373), response to haloperidol (374) (an anti-psychotic medication), systemic lupus erythematosus (SLE) (375), lipid balance (376) and triglyceride metabolism in mouse adipocytes (377), as well as, in humans, T2DM (378). This evidence concerns the gene ARID5B and acute lymphoblastic leukemia.