Other genes of interest from mouse, that differ from human in N-hCR length, include MDR1 and CFTR (a Salmonella receptor), and TNFRSF16/BEX3A/NGFRAP1 (implicated in diabetes) (88) as well as the redox regulators: GCLC (89) and TXNIP (90) (the former encodes the first, rate limiting, enzyme in the glutathione synthesis pathway and has been associated with cardiovascular events) (91); the latter encodes a conserved thioredoxin binding protein that has an 8N-hCR in mice, vs. a 3N-hCR in nonrodent mammals. The gene discussed is CFTR; the disease is diabetes mellitus.