RYR2 and hypertensive disorder: In a GWAS of seven common diseases, hypertension was most closely associated with two linked N-hCR-bearing-genes, RYR2 and CHRM3. RYR2 is involved with heart disease (351) and associated with lipid levels (352) and ALL (266), CHRM33N-hCR is associated with response to an antidiabetic drug in African Americans (353) (cf. CHRM24N-hCR associated with metabolic syndrome) (354).