SCGB1A1 and melanoma: SCGB1A1 also exhibits tumor suppressor activity as demonstrated by decreased invasiveness of human lung adenocarcinoma-derived A549 cells in vitro [12], and the increased incidence of tumors in chemical carcinogenesis bioassay and the increased lung metastasis of B16F10 melanoma cells using Scgb1a1-null mice in vivo [13, 14].