D2HGDH and diffuse large B-cell lymphoma: Nonetheless, upon reviewing recent systematic genetic screens of various solid tumours and of the related Burkitt lymphoma29 we noted the presence of rare somatic D2HGDH mutations with similar features of those that we found in DLBCL, including: targeting of highly conserved residues, primarily missense changes, heterozygous status, clustering in two protein regions and, on occasion, previous description in families with type I D-2-hydroxyglutaric aciduria (Supplementary Table 9).