Importantly, although some of the DLBCL cell lines and primary tumours examined harbour mutations in histone methylation regulators (Supplementary Tables 7 and 8), the presence of these abnormalities, appears to not influence the D2HGDH-driven separation in groups of samples with high and low H3K4/K9 methylation levels. The gene discussed is D2HGDH; the disease is neoplasm.