One notable distinction between our data and those derived from somatic gain-of-function IDH1/2 mutation or bi-allelic loss of D2HGDH in the germline, is that the principal metabolic consequence of the heterozygous D2HGDH mutations found in DLBCL is deficiency of α-KG, not massive accumulation of D2-HG. This evidence concerns the gene IDH1 and diffuse large B-cell lymphoma.