Although the abundance of these metabolites varied greatly across these samples, when taken as a group we found lower levels of α-KG (but not higher levels of D2-HG) in D2HGDH-mutant compared with WT samples; this observation correlated well with a trend for lower expression of IDH2 in D2HGDH mutant DLBCL cell lines (Supplementary Fig. 12). This evidence concerns the gene IDH2 and diffuse large B-cell lymphoma.