The IDH1/2 exons that encode the 2HG-producing mutations (G97, Y100 and R132, IDH1; R140 and R172, IDH2)24 were also sequenced in all D2HGDH-mutant tumours, alongside 74 other DLBCL cases, and were found to be in the wild-type (WT) configuration. Here, D2HGDH is linked to diffuse large B-cell lymphoma.