Accordingly, dysregulation of CREB activity has been implicated in various CNS disorders, including AD, Huntington’s disease, Parkinson’s disease, ischaemia and addiction (Walton & Dragunow, 2000; Nucifora et al., 2001; Ma et al., 2007; Sawamura et al., 2008). This evidence concerns the gene CREB1 and central nervous system disorder.