PEBP1 and colorectal cancer: To investigate the role of RKIP in human colorectal cancer invasion and metastasis, matrigel invasion assay was used to detect the difference of invasion and metastatic ability in SW1116 cells, SW1116/ RKIP— cells, LoVo cells and LoVo cells transfected with pIRES2-EGFP/PEBP-1.