A multivariate analysis indicated that the combination of pre and postoperative PNI (p = 0.001), histological type (p = 0.044), the number of lymph node metastases (p = 0.022) and the preoperative CEA level (p = 0.037) were independent risk factors for mortality. The gene discussed is CEACAM5; the disease is metastatic malignant neoplasm in the lymph nodes.