ELANE and lung cancer: To evaluate the anti-metastatic effect of EGCG on lung cancer with neutrophil elastase involvement in vitro, we first treated the metastatic A549 cells with various concentrations of neutrophil elastase (20–160 nM), EGCG (up to 50 μM) or EGCG (up to 50 μM) and neutrophil elastase (10 nM).