To clarify whether malignant cellular behavior associated with increased expression of EphA2 was dependent on FAK or RhoA in the non-metastatic RCC cells, we examined the effects of FAK and RhoA siRNA-mediated knockdown on malignant cellular behavior in non-metastatic RCC cell lines (Caki-2 and A498) (Fig 8). Here, PTK2 is linked to renal cell carcinoma.