In the non-metastatic RCC cells (Caki-2 and A498), FAK siRNA treatment significantly promoted apoptosis (Fig 8B) while it significantly decreased cellular invasiveness and protein expression of membrane-bound RhoA without changing EphA2 protein expression at 48 hours following transfection (Fig 8A and 8C). Here, EPHA2 is linked to renal cell carcinoma.