Treatment with EphA2 siRNA significantly reduced the expression of membrane-bound RhoA protein in the non-metastatic RCC cell lines (Caki-2 and A498) (Fig 7B and 7D) but not in the metastatic RCC cell lines (Caki-1 or ACHN) (Fig 7A and 7C). This evidence concerns the gene RHOA and renal cell carcinoma.