EPHA2 and renal cell carcinoma: One of the interesting findings revealed in this study is the observation that EphA2 siRNA treatment can significantly attenuate FAK phosphorylation and expression of membrane-bound RhoA in non-metastatic RCC cells but not in metastatic RCC cells, which is consistent with the corresponding results about viability, resistance to apoptosis and invasion after EphA2 siRNA transfection.