GPBAR1 and cholestasis: By using GPBAR1-/- mice we demonstrate that while this receptor mediates the acute pruritogenic effects of intradermal injection of bile acids and other natural GPBAR1 ligands in naïve mice, this pathway appears deactivated in rodent models of cholestasis highlighting the complex interplay between bile acids and their receptors in the determinism of itching and providing an additional explanation for the lack of correlation between plasma bile acids and itching in clinical setting.