STAT3 and familial pancreatic carcinoma: For instance, curcumin has been shown to downregulate transcription factors linked to cancer progression, including NF-κB and STAT3, resulting in depletion of downstream survival targets including BcL-2, BcL-XL, cyclin D1, cIAP1 and Survivin and subsequent apoptotic cell death in pancreatic cancer cells [15, 59].