SP1 and hepatocellular carcinoma: The invasive ability of miR-324-5p-inhibited HCC cells transfected with ETS1 or SP1-specific siRNA, or both siRNAs, measured by transwell matrix penetration assay, revealed that silencing ETS1 or SP1 expression in miR-324-5p-repressed cells could reverse the promotive effect of the miR-324-5p inhibitor on HCC cell migration and invasion (Fig 5B).