The analysis between the different ACE genotypes in vitiligo patients showed statistically significant higher VIDA score (P = 0.007), higher serum ACE (P < 0.001), higher serum IL-6 (P < 0.001) and higher serum nitrite (P = 0.007) in patients with the DD genotype, while the extent of disease did not differ statistically between the 3 groups (Table 5). Here, IL6 is linked to vitiligo.