To clarify the association between the variants of these two candidate genes involved in the vitamin D endocrine system and the risk of mite-sensitized PER in the Han Chinese population, we conducted a case-control study to analyze five selected SNPs in VDR and CYP2R1. To the best of our knowledge, this is the first study reported to evaluate the relationship between VDR and CYP2R1 genetic variations and allergic rhinitis. Here, CYP2R1 is linked to allergic rhinitis.