As for subgroups of presence of asthma and total IgE levels, based on the results that no significant differences were found between VDR or CYP2R1 genotypes with all the relevant PER subgroups, it is suggested that asthma and total IgE levels have no influence upon the relationship between VDR or CYP2R1 genotypes and the risk of mite-sensitized PER in our study. The gene discussed is CYP2R1; the disease is asthma.