We found no evidence that somatic HOXB13 mutations are common in prostate carcinogenesis, something that is compatible with the data in the Catalogue of Somatic Mutations in Cancer (COSMIC, http://cancer.sanger.ac.uk/cosmic/, accessed on May 15th 2015) showing only two mutations in 521 prostate carcinomas tested. The gene discussed is HOXB13; the disease is prostate carcinoma.