Important genes in the MAD3 transcriptome involved in keratinocyte proliferation (Ki-67), keratinocyte adhesion (cadherin 26 and desmocollin 2), TH17-regulated cytokines (IL-1B, IL-36A, CXCL1, CXCL2, and CXCL8), TH1-regulated cytokines (CXCL11), anti-inflammatory cytokine (IL-37), lipid metabolism (LEP, LPL, APOBEC3A, APOBEC3A, CH25H, and APOD), cardiovascular disease (RBP4), and angiogenesis (ANG) were dysregulated between lesional versus non-lesional skin more strongly in thick plaque psoriasis compared to thin plaque psoriasis (Table 3). The gene discussed is LEP; the disease is cardiovascular disorder.