PGC1α and ATGL mRNA and protein expression levels were also significantly increased by OM, OM2 and OM4 at 25μmol·L -1 but not by chromium (III) at 30μmol·L -1 to 60μmol·L -1 concentration range (Fig 1C–1F). This evidence concerns the gene PPARGC1A and ocular melanoma.