TLR3 and viral infectious disease: Many studies have found that mast cells could be involved in virus infection using TLR3, RIG‐I, and MDA5 to sense viral RNA.43, 44, 45 In our study, the expression of TLR3 and TRIF in the lungs of SCG‐treated mice decreased, which suggested that SCG might have some roles in the TLR3 pathway in mast cells during H5N1 infection.