It may interact with low density lipoprotein receptor-related protein (LRP) to help maintain the balance between proteases and inhibitors[28,29,30], regulate N-cadherin-mediated cell adhesion[30], inhibit vascular permeability[15,31,32,33], reduce cerebral infarct volume and protect neurons from ischemia-induced apoptosis[16,17,34]. Here, CDH2 is linked to ischemia.