As shown in S3 Fig, the expression of Glut 1 was decreased on the membrane of A549 and PC-9 cells treated with AZD2014 for 48 h, suggesting that the glycolysis metabolism reduction in NSCLC caused by mTORC inhibitor maybe through downregulating glucose transporter Glut1 expression on the cell membrane. This evidence concerns the gene SLC2A1 and non-small cell lung carcinoma.