CXCR4 is expressed on lymphocytes, hematopoietic stem cells, endothelial and epithelial cells, as well as multiple types of cancer cells, including breast cancer, ovarian cancer, prostate cancer pancreatic cancer, melanoma, esophageal cancer, lung cancer, bladder cancer, osteosarcoma, neuroblastoma, leukemia, gastric cancer, and nasopharyngeal carcinoma [22, 23]. This evidence concerns the gene CXCR4 and melanoma.