Earlier, we used EpApt for the delivery of doxorubicin to RB cells sparing non-malignant cells[19] and then utilized bio-orthogonal chemistry based labeled EpCAM DNA aptamer(EpD) for imaging of cancer cells [40].We showed chimeric EpCAM and nucleolin aptamer targeted super paramagnetic iron oxide nanoparticles(SPION) saturated lactoferrin, with promising anti-tumor property in vitro and in vivo[41]. The gene discussed is EPCAM; the disease is cancer.