EPCAM and neoplasm: Until 2009, the role of EpCAM in cell proliferation was not elucidated and later it was found to be regulated through the intramembrane proteolysis and release of EpICD, that translocate to nucleus for mediating transcription of gene that promotes cell proliferation[7].Hence, we anticipated EpCAM targeting with chimeric construct will have higher anti-tumor activity, as the EpCAM expressing cells can only uptake the construct and result in cell proliferation inhibition mediated by EpCAM silencing.