The observed association with baseline CRP was consistent with findings from a review of observational studies by Hong et al.,[16] where the pooled OR from the meta-analysis of studies examining low vs high levels of CRP (commonly <1.1 vs ≥3mg/L) using both early and late AMD as an outcome was 1.31 (95% CI = 1.04–1.65), which is similar to our results (OR = 1.11 95%CI = 1.00–1.23 for a nearly 3 fold increase). This evidence concerns the gene CRP and age-related macular degeneration.