CAV1 and progeroid syndrome: In conclusion, we have identified a heterozygous loss-of-function mutation in CAV1 in a young patient with a neonatal lipodystrophy and progeroid syndrome, and identified dysregulated pathways that might be important in the contribution to her phenotypic features, including apoptosis, DNA replication, DNA repair, cellular responses to stress, mitochondrial TCA and respiratory electron transport.