In this study of 4990 incident insulin users suffering from type 2 diabetes, who were followed up for 23179 person-years, there was a statistical significant benefit from cumulative time exposure to insulin glargine for specific mortality due to cardiovascular diseases (SHR 0.963, CI 95% 0.944–0.981, p < 0.001). Here, INS is linked to type 2 diabetes mellitus.