These potential antigens included the following: antigen isolated from immunoselected melanoma-2, Aim2, antigen recognized by T-cells (ART)-4, calgranulin, carcinoembryonic antigen, cyclophilin B, polycomb group protein enhancer of zeste homolog 2 (EZH2), gBK, melanoma glycoprotein-100 (GP100; also called Pmel 17), livin, Mage-1, Mage-A4, Mage-A10, multidrug-resistance protein-3 (MRP-3), preferentially expressed antigen in melanoma (PRAME), PTH-rP, squamous cell carcinoma ARTs (Sart)-1, Sart-3, the transcription factor Sox2, TARA, hTert, Trp-1, TTR, and Xage-1B. The gene discussed is SOX2; the disease is melanoma.