Nivolumab received U.S. Food and Drug Administration (FDA) approval in March 2015 and can be used for treating patients with advanced squamous NSCLC that progressed on or after platinum-based chemotherapy according to the CheckMate 017 phase III trial, which included squamous NSCLC patients regardless of their PD-L1 status. This evidence concerns the gene CD274 and non-small cell lung carcinoma.