CD274 and non-small cell lung carcinoma: Pembrolizumab for treating NSCLC is currently subjected to clinical trials, such as a phase I trial among advanced PD-L1-positive NSCLC patients (NCT02007070), a phase II/III study involving two doses of pembrolizumab vs. docetaxel for patients previously treated with PD-L1 positive NSCLC (NCT01905657), and combination studies with ipilimumab or chemotherapy for NSCLC patients (NCT02039674).