Also ongoing are an open-labeled, randomized, phase III trials of nivolumab vs. investigator’s choice of chemotherapy (gemcitabine, cisplatin, carboplatin, paclitaxel, or pemetrexed) as first-line therapy for stage IV or recurrent PD-L1-positive NSCLC, and a phase I study of nivolumab in combination with gemcitabine/cisplatin, pemetrexed/cisplatin, carboplatin/paclitaxel, bevacizumab maintenance, erlotinib, ipilimumab, or as monotherapy in patients with stage IIIb/IV NSCLC. This evidence concerns the gene CD274 and non-small cell lung carcinoma.