Most recently, Ansen et al. 11reported that PD-L1 expression was associated with distinct genotypes of EGFR, KRAS, and STK11 in the two most common histological NSCLC subtypes (i.e., adenocarcinoma and squamous cell carcinoma) in the 2014 ASCO Annual Meeting. This evidence concerns the gene CD274 and adenocarcinoma.