The two groups were matched for age, weight, height, body mass index (BMI), age at first menstruation (menarche), the duration of menopause, number of pregnancies, serum follicle-stimulating hormone (FSH) level, the test scores of depression (BDI) and the frequency of hot flashes per week In the SG, 50% were employed and64.7% had a high school diploma or higher education, while in the CG, 34.2% were employed and 47.8% had a high school diploma or higher degrees. The gene discussed is BRD2; the disease is depressive disorder.