BDNF and depressive disorder: Moreover, the higher DNA methylation in BDNF CT genotype carriers was confirmed in a second group of women with anxiety/depression disorders and healthy controls (3.36 ± 0.15 N = 4 vs. 2.93 ± 0.08 N = 4; t-test p = 0.0022), while CC and TT carriers (N = 4 each) showed no significant differences.