ICA1 and infection: When comparing grapevine genotypes resistant and susceptible to Plasmopara viticola, a subtilisin-like protein sharing sequence similarity with the tomato P69 (a PR protein specifically induced following pathogen infection) was shown to be constitutively expressed in the resistant genotype; and its expression was induced after pathogen infection (Vartapetian et al., 2011; Monteiro et al., 2013; Figueiredo et al., 2014).