C1q−/− mice show key features of preeclampsia, such as hypertension, albuminuria, endotheliosis, decreased placental vascular endothelial growth factor (VEGF), increased soluble VEGF receptor 1 (sFlt-1), increased oxidative stress, decreased blood flow, increased fetal death, diminished litter size, abnormal invasion of trophoblasts, and increased levels of STAT-8 (inhibitor of trophoblast migration) (139). The gene discussed is VEGFA; the disease is preeclampsia.