HMOX1 and Schnyder corneal dystrophy: Although protection against redox-active iron was not part of the studies, earlier work (see Section Coordination of Extracellular and Intracellular Defenses May Be Needed under Specific Circumstances to Survive Heme Toxicity) and extended more recently (Vercellotti et al., 2014) showed a key role for the ferroxidase H-ferritin subunit in spleen and liver to protect cells in SCD mice; but considered independent of HO-1 activity (Vercellotti et al., 2014).