Diminished E-cadherin expression is commonly found in all grades of meningioma [50], and in our study, the original patient tumor, mouse xenograft tumors, and all cell lines were negative for E-cadherin immunostaining (see Figure 4) despite the genomic amplification of the CDH1 gene (which encodes E-cadherin) identified in the cells (see Additional file 2: Table S2), implying that the mesenchymal phenotype predominates. The gene discussed is CDH1; the disease is neoplasm.