Furthermore, the higher proportion of cells with the aberrant karyotype and higher magnitude of amplification of cancer-related genes identified by aCGH, particularly in chromosomes 1, 9, 12, 15, 17, and 20 which are known chromosomal gains in atypical and malignant meningioma [25], suggest that, although initially a minor subclone in the original meningioma tumor, the round cells with the high proliferative activity (KCI-MENG1-HP) are likely to be the tumorigenic cells responsible for the tumor development and growth in the patient. The gene discussed is HP; the disease is meningioma.