We report that TEPA treatment reversed the EMT phenotype; down-regulated the expression of many EMT-related genes including vimentin, fibronectin and transcription factors, Snail and Twist-1; inhibited cell adhesion, migration, and invasion; halted tumor growth and progression; and significantly enhanced the survival of mouse xenografted with EMT6 breast cancer cells. This evidence concerns the gene FN1 and breast carcinoma.