A cytokine pattern similar to that found in AML patients was observed in CD4+ co-cultured directly at a 1:1 ratio, with a significant reduction in IFN-γ (P = 0.0008) and IL-4-positive cells (P = 3.2E−05) and a strong increase in the percentage of CD4+ IL-17A/IL-10-secreting cells (0.02 ± 0.05 and 0.56 ± 0.5% before and after co-culture respectively; P = 0.008). This evidence concerns the gene IL10 and acute myeloid leukemia.